This is a legitimate, though less specific, because labeled “oligo” means “few.” And so the confusion grows. The term “neuropeptide” is a little potential to unravel the secrets of these peptide molecules. Neuropeptides are grouped into families based on similarities in their amino acid sequences. There are the Tachykinins; the insulin, somatostatin, gastrin and cholecystokinin used to diagnose the problems of the gallbladder and pancreas, and opioids such as enkephalins? body’s own opiates or painkillers. As to how neuropeptides might affect the skin, summarized in the July / August 2003 Annals of states: “There is increasing evidence that cutaneous nerve fibers play a modulatory role in a variety of acute and chronic skin. From local interactions between cells in the skin, skin immune components and neuronal tissues occur specially through neuropeptides? Neuropeptide-related functions and skin immune cells and nerve fibers … in the inflammatory responses cutaneous hypersensitivity reactions and dermatoses, namely psoriasis, atopic dermatitis, leprosy and alopecia. “Now that you know that a neuropeptide has a role in central nervous system and that a pentapeptide might also be a neuropeptide Y (which has five amino acids in its chain) but not all neuropeptides are pentapeptides, how can you decide if you pay the extra money for the exciting new neuropeptide creams? You want proof that they are effective enough to justify the higher price, right? In sorting through all the peptides currently touted for antiaging skin care, I have decided that can be placed in one of three groups, depending on the quantity and quality of published research and development behind its use in skin care. .

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